Monitoring Software | LC-MS Proteomics| LC-MS Quality Control


QuiC ™

Next Generation Proteomics Facility Management.

Generates liquid chromatography (LC) and mass spectrometer (MS) QC readouts in near real-time from raw files of various LC-MS vendors across various workflows (SRM/MRM, PRM, DIA, DDA).

Requires Biognosys iRT Kit to enable automated, fast and accurate QC monitoring of your data sets.

      LC-MS based proteomics has become the method of choice for the comprehensive identification and quantification of proteins over large sample sets. Robust and accurate quality controls (QC) during data acquisition and in between instrument maintenance are essential to ensure that high-quality data with low systematic errors are collected.

      QuiC is a simple tool that generates QC readouts in near real-time which are of tremendous help for the LC-MS expert but can be interpreted also by non-mass spec experts. QuiC can be set up to regularly check folders for new raw files which can be used to continuously monitor instrument performance. A multitude of readouts are provided, the most important ones are based on the iRT peptides. For DIA and DDA additional readouts for a background proteome are also provided. This tool enables users to judge data quality and intervene as needed to prevent sample loss, LC-MS downtime, and low data quality.

      Supported Instruments


      • Thermo Scientific™ Orbitrap Exploris™ 480
      • Thermo Scientific™ Orbitrap Eclipse™ Tribrid™
      • Thermo Scientific™ Q Exactive™ Series
      • Thermo Scientific™ Orbitrap Fusion™ Series
      • Thermo Scientific™ Orbitrap Elite™
      • Thermo Scientific™ TSQ Series™
      • SCIEX TripleTOF® Series
      • SCIEX Triple Quad Series
      • SCIEX QTRAP Series
      • SCIEX API Series
      • Agilent 6400 Series
      • Bruker Impact II
      • Bruker timsTOF™ and timsTOF™ Pro
      • Waters Xevo® G2-XS
      • Waters Xevo® TQ-S
      Supported Workflows


      • Selected or Multiple Reaction Monitoring (SRM/MRM)
      • Parallel reaction monitoring (PRM)
      • Data-independent acquisition (DIA) or SWATH
      • Data-dependent acquisition (DDA)
      Recommended System Requirements


      • Windows 10 x64
      • Intel or AMD CPU with 4 cores or more
      • 500 GB of hard drive space
      • 16 GB of memory or more

      If you are interested in ordering one of our software, please submit a request form or contact us. Our team will review your inquiry and get back to you within 5 working days.

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