Tissue Protein Profiling | Novel Biomarkers | Translational Biomarkers

Tissue Biomarker Discovery

Discover your tissue biomarker candidates with unprecedented depth and throughput

Biomarkers play a vital role in precision medicine, from the development of novel targeted therapies and diagnostics to clinical biomarker applications. Biognosys’ Tissue Biomarker Discovery service offers a proteome coverage of 13,800 proteins to identify the most promising, actionable biomarkers to support clinical decision-making.

    Description

    Our TrueDiscovery™ platform for tissue biomarker discovery utilizes Hyper Reaction Monitoring (HRM™). This proprietary Biognosys technology enables specific and unbiased discovery through the quantification of complete proteomes and phospho-proteomes. Further, the platform leverages our flagship software, Spectronaut®, for Artificial Intelligence and Machine Learning (AI/ML) enhanced proteomics data analysis.

    The service offers a choice of depth for the identification of differentially regulated proteins in a hypothesis-free manner. We also provide highly multiplexed targeted proteomics with absolute quantification for customized panels of proteins.

    Tissue Biomarker Discovery can be applied on a large scale, analyzing thousands of proteins across thousands of samples in a high-throughput mode.

    “Biognosys’ high depth and high throughput proteomics technology allows us to take an unbiased deep dive into the molecular mechanisms underlying cancer. Furthermore, the data quality will facilitate our Pan-Cancer therapeutic target and biomarker discovery work-flows, giving us confidence that novel findings closely represent the underlying patient biology.”

    Jonathan Woodsmith, Ph.D.,
    VP Advanced Analytics and AI, Indivumed

    Resources

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    Deliverables

    The results are presented and discussed with you in a dedicated conference call and delivered electronically in PDF and Excel formats.

    Executive Summary
    Materials and Methods
    (suitable for publication)
    Complete Data Matrix

    a) Normalized relative protein intensities for all detected proteins or absolute quantities if stable isotope standards were used
    b)
    Protein annotation (based on Uniprot Knowledgebase)

    Data Interpretation

    a) Differentially regulated proteins with regulation factor and p-value
    b) Coefficient of variation analysis
    c) Multivariate analysis (e.g. PCA)
    d) Hierarchical clustering analysis
    e) Functional analysis (e.g. GO/Pathway analysis)
    f) Custom analysis upon request

    Sample types and depths

    Tissue Biomarker Discovery can be applied to all types of solid biological matrices, such as frozen tissue, FFPE slides, or cell cultures from virtually any species. Only a limited amount of material is required.

    SAMPLE REQUIREMENTS

    Project management

    Biognosys is committed to providing the best possible results to our customers at the fastest possible project turnaround time.

    WORKING WITH US

     

    Helpdesk

    Access our knowledge base with relevant resources and guiding information.

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