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How Can Library-Free directDIA Improve Immunopeptidomics with Spectronaut 20?

For researchers in immunopeptidomics, the ability to capture a complete picture of the peptides presented by MHC molecules is central to understanding immune function and advancing therapeutic design. These peptides determine how the immune system distinguishes self from non-self and, as such, lie at the heart of many cutting-edge applications: vaccine development, cancer immunotherapy, autoimmune disease research, and more. Yet, despite its promise, immunopeptidomics remains one of the most technically challenging applications of mass spectrometry.