Biomarker Panels | Parallel Reaction Monitoring

Clinical Biomarker Panels

Customized multi-biomarker panels for efficacy and safety monitoring in clinical studies.

Reliable biomarkers are fundamental for the success of clinical studies. Establishing effective biomarkers speeds up the decision-making in early drug development and supports clinical trial advancement. Our clinical biomarker panels enable accurate qualitative and quantitative validation and monitoring of custom biomarker panels to ensure drug development success.

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      By selecting any or all of the topic preferences below, you agree to receive respective information from Biognosys via email. You can unsubscribe from these communications at any time. By submitting this form, you confirm that you consent to Biognosys processing of your personal data for the purposes and in the manner as described in our Privacy Notice.

      Description

      The inability to demonstrate efficacy or presence of safety concerns are among the primary reasons why clinical trials fail¹.

      Our TrueSignature® clinical biomarker panels help overcome these obstacles in drug development and offer a solution to reliably monitor biomarkers.

      The panels offer versatile protein combination options, encompassing single proteins, multiplex panels of up to 50 proteins, and even hyperplex panels of up to 800 proteins. The panels can be customized for various therapeutic areas to best suit your research goals.

      The TrueSignature platform is powered by Parallel Reaction Monitoring (PRM) and SureQuant mass spectrometry. These technologies allow for complete customization down to amino acid resolution (i.e. mutations, truncations, isoforms) and are not dependent on affinity-based recognition and reagent availability. You select the proteins; we analyze them for you.

      TrueSignature panels can be developed within weeks and are available both as a standalone solution or an integrated solution, in which insights from TrueDiscovery® studies help guide the choice of peptides in the custom panel.

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      Deliverables

      The results are presented and discussed with you in a dedicated conference call and delivered electronically in PDF and Excel format.

      Executive Summary
      Materials and Methods
      (suitable for publication)
      Complete Data Matrix

      a) Peptide and protein relative intensities for all study samples
      b)
      Peptide and protein absolute quantities based on stable isotope standards (if applicable)

      Data Interpretation

      a) Differentially regulated proteins with regulation factor and p-value
      b) Coefficient of variation analysis
      c) Multivariate analysis (e.g., PCA)
      d) Hierarchical clustering analysis
      e) Custom analysis upon request

      Sample types and depths

      Our Clinical Biomarker Panels solution can be applied to virtually any kind of sample type with minimal sample input.

      SAMPLE REQUIREMENTS

      Project management

      Biognosys is committed to providing the best possible results to our customers at the fastest possible project turnaround time.

      WORKING WITH US

       

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