Gillet L, Navarro P, Tate S, Röst H, Selevsek N, Reiter L, Bonner R, Aebersold R. MCP.
This work introduced the targeted extraction of MS/MS spectra generated by DIA/SWATH using fragment ion spectral libraries. The consistency and accuracy of quantification were comparable to MRM, the gold standard in proteomics quantification. This technology marked a breakthrough in terms of single shot label free quantification in proteomics becaused it drastically reduced the number of missing values while increasing depth and precision of quantification.
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