Targeted proteomics focuses on the measurement of a selected set of proteins that need to be quantified with high sensitivity, quantitative accuracy, and reproducibility. With SpectroDive 10, it is easier than ever to quantify target proteins thanks to a streamlined panel generation process and reliable automated peptide identification. We are hosting two speakers as part of this seminar.
In our first presentation, Tejas Gandhi from Biognosys will introduce the new, seamless SureQuant integration and demonstrate how SpectroDive can boost your productivity for targeted proteomics workflows, especially when analyzing large-scale datasets.
In the second presentation, Simone Di Sanzo from Alessandro Ori’s lab will share their latest research on mapping sites of carboxymethyllysine modification in proteins to reveal associated consequences for proteostasis and cell proliferation. Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products (AGEs) has been shown to accumulate during aging and age-associated diseases but specific protein targets remain largely unexplored. The Ori lab devised a proteomic strategy to identify specific sites of carboxymethyllysine (CML) modification, one of the most abundant AGEs, and precisely quantify changes of abundance in a site-specific manner by PRM.