HUPO 2025

We are proud to announce our participation in HUPO 2025. This year, we are heading to Toronto, Canada with a number of exciting activities including:

breakfast seminar
oral presentations

scientific posters
exhibition booth

Plasma Proteomics and Immunopeptidomics: Expert Solutions for Real-World Research Challenges

Tuesday, Nov 11, 2025 | 8:00 – 9:00 AM | Pier 4&5

Biognosys, in partnership with PreOmics, showcases the latest advances in mass spectrometry–based plasma proteomics and immunopeptidomics. A pilot study using P2 Plasma Enrichment Technology explores circulating biomarkers predictive of treatment response in breast cancer, complementing insights from Olink. Two immunopeptidomics studies with Spectronaut 20 reveal kinase-regulated tumor antigens in chronic myeloid leukemia and show how ERAP1 inhibition reshapes the HLA-B*27:05 immunopeptidome in autoimmunity. Join us to explore these cutting-edge technologies and their translational impact on biomarker discovery.

Agenda

8:00 – 8:05 AM      Introduction – Oliver Rinner, CEO of Biognosys

8:05 – 8:20 AM      ”Circulating biomarkers of treatment response – Insights from a mass spectrometry enabled pilot study” – Jochen Schwenk, PhD, Professor and Platform Scientific Director, Clinical Proteomics and Immunology, KTH Royal Institute of Technology, Stockholm, Sweden

8:20 – 8:35 AM      ”High sensitivity immunopeptidomics discovers kinase regulated tumor antigens in CML” – Maria Wahle, PhD, Postdoctoral Researcher, Mathias Mann Lab, Max Planck Institute of Biochemistry, Martinsried, Germany

8:35 – 8:50 AM      ”Using immunopeptidomics to understand how ERAP1 inhibition reshapes the HLA-B*27:05 immunopeptidome and abrogates presentation of putative Axial Spondyloarthritis autoantigens” – Daniel Green, PhD – Head of Bioinformatics at Greywolf Therapeutics, Oxford, UK

8:50 – 9:00 AM      Q&A

Plasma Proteomic Signatures Predict Progression-Free Survival in NSCLC Patients undergoing anti-PD-L1 and Chemotherapy

Presenter: Yuehan Feng

Date: Tuesday, Nov 11, 2025
Time: 10:20 – 11:50 AM

Frontenac Ballroom

Robust Inter-Laboratory Performance of the P2 Workflow for Deep Plasma Proteomics

Presenter: Hasmik Keshishian

Date: Tuesday, Nov 11, 2025
Time: 10:20 – 11:50 AM

Pier 4 – 5

Identifying Circulating Biomarkers for Amyloid Conversion and Early Cognitive Decline Through Unbiased Proteomics in Matched CSF and Plasma

Presenter: Yuehan Feng

Date: Wednesday, Nov 12, 2025
Time: 3:15 – 4:20 PM

Frontenac Ballroom

Digital Proteome: A Multi-Species, Multi-Tissue Proteome Expression Atlas Supporting Target Discovery and Validation

Presenter: Yuehan Feng

Date: Monday, Nov 10
Time: 1:15 – 3:15 PM

Poster number: PV.01.071

Harnessing the Ion Mobility Dimension to Improve Quantification in dia-PASEF

Presenter: Brendan Rickert

Date: Monday, Nov 10
Time: 1:15 – 3:15 PM

Poster number: PV.01.177

OmicsFlow: Scalable Software for Multi-Platform Large-Scale Proteomics

Presenter: Damiano Robbiani

Date: Monday, Nov 10
Time: 1:15 – 3:15 PM

Poster number: PV.01.014

Proteome-Wide Drug Target Identification and Binding Site Mapping Using LiP-MS

Presenter: Yuehan Feng

Date: Tuesday, Nov 11
Time: 1:15 – 3:15 PM

Poster number: PV.02.004

Systematic Assessment of Entrapment Approaches for FDR Validation in DIA proteomics

Presenter: Monika Pepelnjak

Date: Tuesday, Nov 11
Time: 1:15 – 3:15 PM

Poster number: PV.02.111