Surpassing 10 000 Identified and Quantified Proteins in a Single Run by Optimizing Current LC-MS Instrumentation and Data Analysis Strategy - Biognosys

Surpassing 10 000 Identified and Quantified Proteins in a Single Run by Optimizing Current LC-MS Instrumentation and Data Analysis Strategy

Muntel J, Gandhi T, Verbeke L, Bernhardt OM, Treiber T, Bruderer R, and Reiter L. Molecular Omics.

In this study we showed how improvements in chromatography and data analysis can push the proteome coverage in human tissue beyond 10,000 proteins, spanning six orders of magnitude in dynamic range. Such remarkable coverage was achieved using Hybrid Libraries, a novel approach that combines the depth of resource libraries with the high precision of directDIA. Thousands of these proteins could be linked to the hallmarks of testis cancer.

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