Deconvoluting Compound-Target Interactions with Limited Proteolysis (LiP)

This joint webinar with ETH Zurich features Prof. Dr. Paola Picotti, scientific advisor of Biognosys and inventor of the LiP-MS technology. In the first part of the webinar, Prof. Picotti provides an overview on the development of the LiP-MS workflow in her laboratory starting from the concept of detecting protein structural alterations in complex matrices to its various applications in addressing biological questions such as metabolite-protein interactions, protein aggregation and thermal stability. In the second part of this webinar, Biognosys’ senior scientist Dr. Nigel Beaton focuses on establishing a machine learning-based LiP-MS workflow for the deconvolution of small molecule drug targets in an unbiased manner.