Generates liquid chromatography (LC) and mass spectrometer (MS) QC readouts in near real time from raw files of various LC-MS vendors across various workflows (SRM/MRM, PRM, DIA, DDA).
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LC-MS based proteomics has become the method of choice for the comprehensive identification and quantification of proteins over large sample sets. Robust and accurate quality controls (QC) during data acquisition and in between instrument maintenance are essential to ensure that high quality data with low systematic errors is collected.
QuiC is a simple tool that generates QC readouts in near real time which are of tremendous help for the LC-MS expert but can be interpreted also by non-mass spec experts. QuiC can be set up to regularly check folders for new raw files which can be used to continuously monitor instrument performance. A multitude of readouts are provided, the most important ones are based on the iRT peptides. For DIA and DDA additional readouts for a background proteome are also provided. This tool enables users to judge data quality and intervene as needed to prevent sample loss, LC-MS downtime and low data quality.
Minimal: Windows 7 x64, CPU Intel ® Core™ CPU 2.7 GHz (quad core) or similar, HDD 200 GB free space, Memory 8 GB, Software .NET 4.6.1 or higher.
Recommended: Windows 7 x64 or higher, CPU Intel Core i7 4770, 3.4 GHz (octa core) or more, 500 GB free space, solid state drive (SSD), Memory 16 GB or more, Software .NET 4.6.1 or higher.
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QuiC — a fast and easy to use tool for real time quality control readouts of MRM, PRM, DIA and DDA data. Poster MSACL US 2017, San Diego, USA.
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