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Multiplexed Assay Panels

PlasmaDive™

Quantify 100 proteins in a single measurement with unbeatable specificity and precision!

Multiplexed Assay Panel for absolute quantification of 100 proteins in human plasma/serum samples.

Available for 48 or 96 samples and includes a license for the SpectroDive™ software 

PlasmaDive™ 48

Product number: Ki-3004-48

USD

6,750.00

In stock

PlasmaDive™ 96

Product number: Ki-3004-96

USD

12,000.00

In stock

PlasmaDive™ Assay Panel quantifies 100 proteins in a single measurement with unbeatable specificity and precision. It is designed to monitor protein levels in plasma or serum samples with high throughput. PlasmaDive™ sets a new standard for clinical research, biomarker discovery and development of companion diagnostics.

PlasmaDive™ Assay Panel optimally combines 100 peptide MRM or PRM assays in one multiplexed, scheduled method. Each peptide represents a human plasma protein, with almost half of the panel’s proteins being considered a putative cancer, cardio-vascular or metabolic biomarker.

PlasmaDive™ Panel Kit contains

  • Reagents and optimized protocol for reproducible sample preparation
  • Stable isotope standards for accurate quantitation
  • iRT Standard  for transfer to virtually any LC setup
  • MS Method for optimized measurements
  • Either 6 or 12 months license for the SpectroDive™ software
 

List of Proteins

Entry Name
UniPot ID
Description

A1AG1_HUMAN

P02763

Alpha-1-acid glycoprotein 1 (Orosomucoid-1) 

A1AG2_HUMAN

P19652

Alpha-1-acid glycoprotein 2 (Orosomucoid-2) 

A1AT_HUMAN

P01009

Alpha-1-antitrypsin 

A1BG_HUMAN

P04217

Alpha-1B-glycoprotein 

A2AP_HUMAN

P08697

Alpha-2-antiplasmin (Serpin F2)

A2GL_HUMAN

P02750

Leucine-rich alpha-2-glycoprotein (LRG)

A2MG_HUMAN

P01023

Alpha-2-macroglobulin (Alpha-2-M) 

AACT_HUMAN

P01011

Alpha-1-antichymotrypsin (ACT) 

AFAM_HUMAN

P43652

Afamin (Alpha-albumin) 

ALBU_HUMAN

P02768

Serum albumin

ALS_HUMAN

P35858

Insulin-like growth factor-binding protein complex acid labile subunit

AMBP_HUMAN

P02760

Protein AMBP

ANGT_HUMAN

P01019

Angiotensinogen (Serpin A8) 

ANT3_HUMAN

P01008

Antithrombin-III (Serpin C1)

APOA1_HUMAN

P02647

Apolipoprotein A-I 

APOA2_HUMAN

P02652

Apolipoprotein A-II 

APOA4_HUMAN

P06727

Apolipoprotein A-IV 

APOB_HUMAN

P04114

Apolipoprotein B-100 

APOC1_HUMAN

P02654

Apolipoprotein C-I 

APOC2_HUMAN

P02655

Apolipoprotein C-II

APOC3_HUMAN

P02656

Apolipoprotein C-III 

APOD_HUMAN

P05090

Apolipoprotein D 

APOE_HUMAN

P02649

Apolipoprotein E 

APOH_HUMAN

P02749

Apolipoprotein H

APOL1_HUMAN

O14791

Apolipoprotein L1 

APOM_HUMAN

O95445

Apolipoprotein M 

BTD_HUMAN

P43251

Biotinidase

C1QA_HUMAN

P02745

Complement C1q subcomponent subunit A

C1QB_HUMAN

P02746

Complement C1q subcomponent subunit B

C1QC_HUMAN

P02747

Complement C1q subcomponent subunit C

C1R_HUMAN

P00736

Complement C1r subcomponent 

C1S_HUMAN

P09871

Complement C1s subcomponent 

C4BPA_HUMAN

P04003

C4b-binding protein alpha chain 

CBG_HUMAN

P08185

Corticosteroid-binding globulin (Serpin A6) 

CD5L_HUMAN

O43866

CD5 antigen-like (CT-2) (SP-alpha)

CERU_HUMAN

P00450

Ceruloplasmin (Ferroxidase)

CFAB_HUMAN

P00751

Complement factor B 

CFAH_HUMAN

P08603

Complement factor H (H factor 1)

CFAI_HUMAN

P05156

Complement factor I 

CHLE_HUMAN

P06276

Cholinesterase (EC 3.1.1.8)

CLUS_HUMAN

P10909

Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) 

CO2_HUMAN

P06681

Complement C2 

CO3_HUMAN

P01024

Complement C3

CO4A_HUMAN

P0C0L4

Complement C4-A 

CO5_HUMAN

P01031

Complement C5 

CO8A_HUMAN

P07357

Complement component C8 alpha chain 

CO9_HUMAN

P02748

Complement component C9 

CXCL7_HUMAN

P02775

Platelet basic protein (C-X-C motif chemokine 7)

F13A_HUMAN

P00488

Coagulation factor XIII A chain 

F13B_HUMAN

P05160

Coagulation factor XIII B chain

FA10_HUMAN

P00742

Coagulation factor X

FA9_HUMAN

P00740

Coagulation factor IX

FBLN1_HUMAN

P23142

Fibulin-1 

FETUA_HUMAN

P02765

Alpha-2-HS-glycoprotein 

FETUB_HUMAN

Q9UGM5

Fetuin-B 

FIBA_HUMAN

P02671

Fibrinogen alpha chain 

FIBG_HUMAN

P02679

Fibrinogen gamma chain

FINC_HUMAN

P02751

Fibronectin (FN)

GELS_HUMAN

P06396

Gelsolin (Actin-depolymerizing factor)

GPX3_HUMAN

P22352

Glutathione peroxidase 3

HBB_HUMAN

P68871

Hemoglobin subunit beta

HBD_HUMAN

P02042

Hemoglobin subunit delta (Delta-globin)

HEMO_HUMAN

P02790

Hemopexin (Beta-1B-glycoprotein)

HEP2_HUMAN

P05546

Heparin cofactor 2

HPT_HUMAN

P00738

Haptoglobin 

HPTR_HUMAN

P00739

Haptoglobin-related protein

HRG_HUMAN

P04196

Histidine-rich glycoprotein 

IC1_HUMAN

P05155

Plasma protease C1 inhibitor 

IGHA1_HUMAN

P01876

Ig alpha-1 chain C region

IGHA2_HUMAN

P01877

Ig alpha-2 chain C region

IGHG1_HUMAN

P01857

Ig gamma-1 chain C region

IGHG2_HUMAN

P01859

Ig gamma-2 chain C region

IGHG3_HUMAN

P01860

Ig gamma-3 chain C region (HDC) 

IGHM_HUMAN

P01871

Ig mu chain C region

IPSP_HUMAN

P05154

Plasma serine protease inhibitor

ITIH1_HUMAN

P19827

Inter-alpha-trypsin inhibitor heavy chain H1

ITIH2_HUMAN

P19823

Inter-alpha-trypsin inhibitor heavy chain H2

ITIH4_HUMAN

Q14624

Inter-alpha-trypsin inhibitor heavy chain H4

KAIN_HUMAN

P29622

Kallistatin (Kallikrein inhibitor)

KLKB1_HUMAN

P03952

Plasma kallikrein

KNG1_HUMAN

P01042

Kininogen-1

PEDF_HUMAN

P36955

Pigment epithelium-derived factor (PEDF)

PGRP2_HUMAN

Q96PD5

N-acetylmuramoyl-L-alanine amidase

PLF4_HUMAN

P02776

Platelet factor 4 (Oncostatin-A)

PLMN_HUMAN

P00747

Plasminogen

PON1_HUMAN

P27169

Serum paraoxonase

PRG4_HUMAN

Q92954

Proteoglycan 4

RET4_HUMAN

P02753

Retinol-binding protein 4

SAA4_HUMAN

P35542

Serum amyloid A-4 protein

SEPP1_HUMAN

P49908

Selenoprotein P

SHBG_HUMAN

P04278

Sex hormone-binding globulin

TETN_HUMAN

P05452

Tetranectin

THBG_HUMAN

P05543

Thyroxine-binding globulin (Serpin A7)

THRB_HUMAN

P00734

Prothrombin

TRFE_HUMAN

P02787

Serotransferrin

TTHY_HUMAN

P02766

Transthyretin

VTDB_HUMAN

P02774

Vitamin D-binding protein

VTNC_HUMAN

P04004

Vitronectin

VWF_HUMAN

P04275

von Willebrand factor

ZA2G_HUMAN

P25311

Zinc-alpha-2-glycoprotein

Please contact us for support.

PlasmaDive™ 48 Multiplexed Panel Kit components 

  • Reference Peptide Mix (1x 1.1 ml glass vial)
  • Alkylation Solution (1x 10 ml tube)
  • Reduction Stock Solution (1x 0.5 ml tube)
  • LC Solution (2x 10 ml tube)
  • 10x Dilution Buffer (1x 10 ml tube)
  • Denature Buffer (1x 10 ml tube)
  • Dissolution Buffer 1x 2.0 ml tube)
  • 96-well MACROSpin Plate (1x with 2x 96-well plate included)
  • 96-well Plate (3x packaged separately)
  • 96-well Plate Sealer (6x)
  • PlasmaDive™ MRM or PRM Panel Plug-in for SpectroDive software
  • PlasmaDive™ Multiplexed Assay Panel Manual
  • 6 months license for the SpectroDive™ software 

 

PlasmaDive™ 96 Multiplexed Panel Kit components 

  • Reference Peptide Mix (2x 1.1 ml glass vial)
  • Alkylation Solution (2x 10 ml tube)
  • Reduction Stock Solution (2x 0.5 ml tube)
  • LC Solution (4x 10 ml tube)
  • 10x Dilution Buffer (2x 10 ml tube)
  • Denature Buffer (2x 10 ml tube)
  • Dissolution Buffer (2x 2.0 ml tube)
  • 96-well MACROSpin Plate (1x with 2x 96-well plate included)
  • 96-well Plate (3x packaged separately)
  • 96-well Plate Sealer (6x)
  • PlasmaDive™ MRM or PRM Panel Plug-in for SpectroDive software
  • PlasmaDive™ Multiplexed Assay Panel Manual
  • 12 months license for the SpectroDive™ software 

 

Supported instruments

MRM

  • Thermo Scientific™ TSQ™ Series (Vantage, Quantum, Quantiva)
  • AB SCIEX API 4000™
  • AB SCIEX Triple Quad™ 5500 
  • Agilent 6400 Series
 PRM
  • Thermo Scientific™ Q Exactive™ Series
  • Thermo Scientific™ Orbitrap Fusion™ Series

If your instrument is not on the list please contact us to get detailed information on the instruments we support.

The kit is sufficient for analysis of 96 human plasma or serum samples and allows independent processing of 2 batches of 48 samples each. PlasmaDive™ Multiplexed Assay Panel requires as little as 10 µl of plasma and 48 hours to provide actionable clinically-relevant data. The panel is perfect for large-scale experiments required high throughput.

PlasmaDive™ Multiplexed Assay Panel is also offered as a Service for measurements in Biognosys facility.

Please contact us for support.

Visit Science Hub to access all scientific and technical content (publications, videos, application notes, posters and more) related to Biognosys technology, products and services.

Peer-Reviewed Papers

  1. Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, et. al. Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. J Am Coll Cardiol. 2017;69(7):789-800.
  2. Willeit P, Skroblin P, Moschen AR, Yin X, Kaudewitz D, Zampetaki A, et al. Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes. Diabetes. 2017 Feb;66(2):347-357.
  3. Cantonwine DE, Zhang Z, Rosenblatt K, Goudy KS, Doss RC, Ezrin AM, Page G, Brohman B, Mcelrath TF. Evaluation of proteomic biomarkers associated with circulating microparticles as an effective means to stratify the risk of spontaneous preterm birth. Am J Obstet Gynecol. 2016 Feb 10. doi: 10.1016/j.ajog.2016.02.005.
If we forgot to include your publication that uses our technology, please don’t hesitate to let us know at info@biognosys.com.

Please contact us for support.

What is the difference between PlasmaDive, PlasmaDiveMini and PlasmaDeepDive?

PlasmaDive and PlasmaDiveMini monitor an identical set of 100 proteins levels in human plasma or serum samples with high throughput. Each stable isotope standard peptide represents a human plasma protein, with almost half of the panel’s proteins being considered a putative cancer, cardio-vascular or metabolic biomarker. The difference is only in the number of samples that can be processed. PlasmaDive is made for 96 samples and PlasmaDiveMini is made for 20 samples.

PlasmaDeepDive™ multiplexed assay panel targets 100 proteins to be measured in one scheduled MRM or PRM experiment. It includes 16 peptides corresponding to the typically depleted proteins in human plasma analysis, which can be used to monitor the depletion quality, 9 housekeeping proteins for normalization and consequently high reproducibility of the results, and 75 proteins that represent relevant targets for biomarker screening. 

Can I retrieve the protein identities used in the kits?

Yes, all proteins covered by the respective kits can be found in our online shop, under the support material section of each product. Additional information can be retrieved from the Science Hub section of the Biognosys website. 

What is the dynamic range of PlasmaDive and PlasmaDeepDive combined?

Together the two kits span 6-7 orders of magnitude dynamic range with high precision and reproducibility. Additional information on the targeted proteins and use cases can be found in Science Hub section of the Biognosys website. 

Can I measure only a subset of the proteins in each kit?

Of course, assays of only a subset of the proteins in one kit can be generated and measured. Thereby the measurement time can be reduced and the sensitivity of the analysis increased.

Please contact us for support.

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