Plasma Biomarker Discovery | Translational and Novel Biomarkers

Plasma Biomarker Discovery

Comprehensive plasma biomarker discovery for pre-clinical and clinical research

Our TrueDiscovery® Plasma Biomarker Discovery services deliver the most comprehensive offering on the market, achieving deep, unbiased profiling of up to 9,000 proteins. The high-throughput nature of this workflow makes it ideal for large-scale studies, providing unparalleled specificity and quantitative precision to identify actionable biomarkers.

Our TrueDiscovery services can be combined with NULISA™ high-sensitivity, targeted panels, offering a complete solution for all your plasma proteomics research needs.

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      By selecting any or all of the topic preferences below, you agree to receive respective information from Biognosys via email. You can unsubscribe from these communications at any time. By submitting this form, you confirm that you consent to Biognosys processing of your personal data for the purposes and in the manner as described in our Privacy Notice.

      Description

      The P2 Plasma Enrichment System

      The novel particle-based P2 Plasma Enrichment System achieves the highest reported proteome enrichment with greater reproducibility than any other protein corona-based technology. The optimized single-well sample preparation, combined with optimized particle surface, stabilizes the labile protein corona and provides exceptional quantitative accuracy and depth.

      The offering is driven by Biognosys’ proprietary Data Independent Acquisition (DIA) workflow, powered by Hyper Reaction Monitoring (HRM™) technology. Data analysis is performed using Spectronaut® software, enhanced by Artificial Intelligence and Machine Learning (AI/ML), and supported by the Proteoverse™ data visualization tool.

       

      Licensing P2 for In-house Use

      The P2 Plasma Enrichment technology is also available under licensing for end-users of facilities equipped with high-performance mass spectrometry platforms.

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      Deliverables

      The results are presented and discussed with you in a dedicated conference call and delivered electronically in PDF and Excel formats, as well as via our complimentary data exploration tool, Proteoverse™.

      Executive Summary
      Materials and Methods
      (suitable for publication)
      Complete Data Matrix

      a) Normalized relative protein intensities for all detected proteins or absolute quantities if stable isotope standards were used

      b) Protein annotation (based on Uniprot Knowledgebase)

      Data Analysis

      a) Differentially regulated proteins with regulation factor and p-value
      b) Coefficient of variation analysis
      c) Multivariate analysis (e.g. PCA)
      d) Hierarchical clustering analysis
      e) Functional analysis (e.g. GO/Pathway analysis)
      f) Custom analysis upon request
      g) Complimentary access to Proteoverse

      Data Insights
      Gain actionable insights into unbiased mass spectrometry proteomics data with Proteoverse, our data visualization and exploration tool, offered complimentary with selected services.
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      Sample types and depths

      Plasma Biomarker Discovery can be applied to 200 μl of plasma sample for the P2 Enrichment System (or 50 μl for the NULISAseq targeted assays).

      SAMPLE REQUIREMENTS

      Project management

      Biognosys is committed to providing the best possible results to our customers at the fastest possible project turnaround time.

       

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