The P2 Plasma Enrichment System
The P2 Plasma Enrichment technology redefines plasma proteomics by enabling deep profiling of low-abundance proteins in human plasma. With proprietary nanoparticle-based enrichment and optimized reagents, it delivers unmatched proteome depth, high reproducibility, and high-throughput performance, ideal for large-cohort studies, biomarker discovery, and translational research.
Its single-well workflow and stabilized protein corona chemistry ensure median CVs below 10%, providing reliable quantitative data across complex studies. The technology supports unbiased plasma proteome exploration, including detection of isoforms and post-translational modifications (PTMs), offering new insights into disease mechanisms and molecular pathways.
Integrated with Biognosys’ TrueDiscovery Platform
The P2 Plasma Enrichment workflow is fully integrated with Biognosys’ advanced Data-Independent Acquisition (DIA) mass spectrometry technology within the TrueDiscovery platform. Data processing and quantitative analysis are performed using Spectronaut® software and visualized through Proteoverse®, Biognosys’ interactive platform for plasma proteomics data exploration.
Flexible Access: CRO Services and Plasma Proteomics Kits
The P2 Plasma Enrichment technology is available as a CRO service at Biognosys’ state-of-the-art laboratories in Switzerland and Newton, MA, providing access to high-throughput plasma proteomics analysis without the need for in-house mass spectrometry infrastructure.
For laboratories with high-performance mass spectrometry platforms, the P2-iST Plasma Kit combines Biognosys’ P2 enrichment technology with PreOmics’ iST workflow, enabling scalable processing of up to 192 plasma samples per day with exceptional quantitative precision.
Contact our team to learn more about plasma proteomics CRO services or inquire about the P2-iST Plasma Kit here.
Resources
Brochures & Flyers
Unlocking Plasma Proteomics for High-End Mass Spectrometry Labs
Biognosys’ P2 Enrichment System sets a new standard in proteomics, enabling researchers to uncover low-abundance proteins in human plasma and other biofluids. Built on proprietar [...]
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White Papers
Unlocking Plasma Discoveries: Bridging Depth, Throughput and Sensitivity
Our latest white paper highlights our advanced plasma proteomics capabilities, driven by the P2 Enrichment System. The study demonstrates how TrueDiscovery® Plasma Biomarker Disco [...]
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Posters
Advancing Biomarker Discovery: Characterization of the P2 Technology for Plasma Samples
Poster presented at HUPO 2025
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Seminar Recordings
Accelerating Drug Discovery and Development with Biognosys’ Next-Generation Proteomics Services
Find out what's new in our next-generation proteomics service in this launch seminar recording from ASMS 2024. Know more about our latest P2 Plasma Enrichment System.
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Brochures & Flyers
Private: Biomarker Discovery Brochure – Explore the Unexpected with the Power of Proteomics
The brochure provides you with an overview of the key features and benefits of our next-generation Biomarker Discovery solutions. In addition, the brochure elaborates on our deep a [...]
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White Papers
Private: Accelerating Biomarker Discovery With Large-Scale Plasma Proteomics
Our new White Paper explains how advances in mass spectrometry can now unlock the potential of the plasma proteome, uncovering actionable insights that are essential for biomarker [...]
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Brochures & Flyers
TrueDiscovery – Introducing The P2 Plasma Enrichment System
The novel particle-based P2 Plasma Enrichment System achieves the highest reported proteome enrichment with greater reproducibility than any other protein corona-based workflow. Th [...]
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White Papers
A Comparative Study of Mass Spectrometry and Affinity-based Platforms
Harnessing the information present in the plasma proteome requires robust large-scale analytical techniques. Our latest white paper gives you a better understanding of two leading [...]
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Case Studies
Private: Multi-omics Biomarker Analysis Identifies Unique Immune Activation Signature in Pancreatic Cancer
We describe a first-of-its-kind study using multi-omics biomarker approaches to demonstrate pharmacodynamic effects and immune modulation in pancreatic cancer. Biognosys’ proprie [...]
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Deliverables
The results are presented and discussed with you in a dedicated conference call and delivered electronically in PDF and Excel formats, as well as via our complimentary data exploration tool, Proteoverse™.
Executive Summary
Materials and Methods
(suitable for publication)Complete Data Matrix
a) Normalized relative protein intensities for all detected proteins or absolute quantities if stable isotope standards were used
b) Protein annotation (based on Uniprot Knowledgebase)
Data Analysis
a) Differentially regulated proteins with regulation factor and p-value
b) Coefficient of variation analysis
c) Multivariate analysis (e.g. PCA)
d) Hierarchical clustering analysis
e) Functional analysis (e.g. GO/Pathway analysis)
f) Custom analysis upon request
g) Complimentary access to Proteoverse
Sample types and depths
Plasma Biomarker Discovery can be applied to 200 μl of plasma sample for the P2 Enrichment System (or 50 μl for the NULISAseq targeted assays).
Project management
Biognosys is committed to providing the best possible results to our customers at the fastest possible project turnaround time.
