Biofluids are known to have a high protein dynamic range, requiring a highly robust technology for proteomic analysis. Our TrueDiscovery® platform for biofluid biomarker discovery enables the quantification of biofluid proteomes with unparalleled specificity and depth to identify differentially regulated proteins as biomarker candidates in an unbiased, hypothesis-free manner.
The application offers a proteome coverage of up to 7,000 proteins in plasma or serum, 6,100 proteins in cerebrospinal fluid (CSF), and 11,100 proteins in urine.
We offer a choice of depth of analysis and can identify low-abundant proteins thanks to our highly optimized depletion and sample enrichment workflow.
The service is scalable to thousands of samples with industry-leading throughput.
The platform is powered by Biognosys’ proprietary Hyper Reaction Monitoring (HRM™) technology and Spectronaut® software for Artificial Intelligence and Machine Learning (AI/ML) enhanced proteomics data analysis.
Insights from TrueDiscovery® studies can guide the choice of proteins in follow-on studies with TrueSignature® custom panels. Moreover, our biofluid-based profiling workflows can be combined with our proprietary PQ500™ plasma panel. PQ500 is a reference panel for absolute quantification, developed based on our expertise in targeted proteomics.
Resources
White Papers
A Comparative Study of Mass Spectrometry and Affinity-based Platforms
Harnessing the information present in the plasma proteome requires robust large-scale analytical techniques. Our latest white paper gives you a better understanding of two leading [...]
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White Papers
Accelerating Biomarker Discovery With Large-Scale Plasma Proteomics
Our new White Paper explains how advances in mass spectrometry can now unlock the potential of the plasma proteome, uncovering actionable insights that are essential for biomarker [...]
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White Papers
How To Accelerate And De-Risk Drug Development In Oncology
Our new White Paper explains why oncology drug development fails and how Biognosys’ proteomics platforms and applications can support your oncology research.
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Brochures & Flyers
TrueDiscovery™ Brochure – Unbiased Biological Insights from Tissue and Biofluids
The brochure provides an overview of the key features and benefits of our next-generation TrueDiscovery™ platform. In addition, it elaborates on our deep and reproducible proteom [...]
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Case Studies
Multi-omics Biomarker Analysis Identifies Unique Immune Activation Signature in Pancreatic Cancer
We describe a first-of-its-kind study using multi-omics biomarker approaches to demonstrate pharmacodynamic effects and immune modulation in pancreatic cancer. Biognosys’ proprie [...]
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Seminar Recordings
On-demand Webinars on Science and Nature Research Custom Media
Watch our latest webinars "3D proteome snapshots enable high-resolution functional proteomics screens" and "Immunotherapy meets proteomics: A winning combination for clinical trial [...]
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Seminar Recordings
Plasma Proteomics: The Next Frontier of Biomarker Discovery in the Precision Medicine Era
Plasma proteomics is increasingly recognized as a fundamental approach to accelerate biomarker discovery and drug development, taking precision medicine to the next level.
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Case Studies
Biomarker Candidates for Tumors Identified from Deep‐profiled Plasma Stem Predominantly from the Low Abundant Area
The case study elaborates on the results of our pan-cancer proteomics study. We analyzed 180 plasma samples from lung, breast, colorectal, pancreatic, and prostate cancer using our [...]
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User Resources
Biognosys 3D Protein Explorer
With the 3D Protein Explorer you can visualize the proteomic signature identified with our next-generation Plasma Biomarker Discovery solution in our latest pan-cancer clinical stu [...]
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Case Studies
Next Generation Proteomics Identifies Candidate Biomarkers for Immunotherapy
Immunotherapy significantly improved treatment options for patients with NSCLC. However, not all patients respond equally if at all. In a joint study with Curie Institute (Paris, F [...]
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Case Studies
Biomarker Discovery for Alzheimer’s Disease through Deep Proteomic Profiling of Cerebrospinal Fluid
Cerebrospinal fluid (CSF) is established as a key matrix that enables interrogation of biological processes within the central nervous system. CSF biomarkers may support the develo [...]
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Application Notes
Reproducible and Consistent Results in Large-scale Plasma and Serum Studies with PQ500™ Reference Peptides
This technical note provides an overview of the importance of plasma and serum as biospecimens in clinical practice, the challenges that large sample cohorts pose in MS-based prote [...]
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Publications
Analysis of 1508 Plasma Samples by Capillary-Flow Data-Independent Acquisition Profiles Proteomics of Weight Loss and Maintenance
Bruderer R et al. Molecular & Cellular Proteomics. We have established a robust capillary-flow DIA platform capable of measuring a large number of cli [...]
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Deliverables
The results are presented and discussed with you in a dedicated conference call and delivered electronically in PDF and Excel formats.
Executive Summary
Materials and Methods
(suitable for publication)Complete Data Matrix
a) Normalized relative protein intensities for all detected proteins or absolute quantities if stable isotope standards were used
b) Protein annotation (based on Uniprot Knowledgebase)
Data Interpretation
a) Differentially regulated proteins with regulation factor and p-value
b) Coefficient of variation analysis
c) Multivariate analysis (e.g. PCA)
d) Hierarchical clustering analysis
e) Functional analysis (e.g. GO/Pathway analysis)
f) Custom analysis upon request
Sample types and depths
Biofluid Biomarker Discovery can be applied on blood plasma or serum, urine, cerebrospinal fluid (CSF), or any other similar biofluid from any species
Project management
Biognosys is committed to providing the best possible results to our customers at the fastest possible project turnaround time.
