Dynamic 3D Proteomes Reveal Protein Functional Alterations at High Resolution in Situ

Cappelletti V, Hauser T, Piazza I, Pepelnjak M, Malinovska L, Fuhrer T, Li Y, Dörig C, Boersema P, Gillet L, Grossbach J, Dugourd A, Saez-Rodriguez J, Beyer A, Zamboni N, Caflisch A, Souza N, Picotti P. Cell

In this study, an ETH Zurich team led by Biognosys’ scientific advisor and inventor of the LiP-MS technology, Paola Picotti, has spearheaded the exploration of protein functional states in a proteome-wide manner. The team investigated the role of protein structural alterations as a first-line cellular response. Integrating peptide-level LiP-MS data with orthogonal information such as phosphorylation enabled the linking of protein structural changes to functional implications. This work demonstrates the potential of integrating structural and abundance-based proteomics to achieve deeper insights into biological processes.

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