Proteome profiling of aqueous humor in patients with glaucoma

Biognosys’ Discovery Proteomics Service was used to quantify hundreds of proteins in patients with glaucoma

Today we are highlighting an interesting paper published in PlosOne by researchers from Cantonal Hospital Aarau and University of Basel, Switzerland entitled “Changes to the Aqueous Humor Proteome during Glaucoma”.

The aim of the paper was to investigate the changes in the aqueous humor proteome obtained from five human donors diagnosed with primary open angle glaucoma (POAG) and five age- and sex-matched controls undergoing cataract surgery.

Biognosys’ Discovery Service based on the Next-Generation Proteomics workflow Hyper Reaction Monitoring (HRM-MS™) was used to quantify several hundred proteins in each aqueous humor sample. Expression levels of 87 proteins were found to be significantly different between glaucomatous and control aqueous humor. The authors concluded that glaucoma leads to profound changes to the aqueous humor proteome consistent with an altered metabolic state, an inflammatory response and impaired antioxidant defense.

Read the full paper here.

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