DIVING DEEPER INTO THE PROTEOME
Spectronaut is the most advanced software for DIA proteomics, providing more identifications with a higher level of confidence. Thanks to the embedded search engine Pulsar, it enables complete workflows from library generation to data analysis. With its latest release, Spectronaut establishes novel solutions to current challenges in the field of proteomics.
DIA MEETS CONFIDENT PTM SITE LOCALIZATION
DIA, with its high reproducibility, is inherently well suited for PTM analysis. With a new site localization confidence algorithm, Spectronaut is now fully enabled for robust, sensitive, and reliable PTM quantification.
INCREASE YOUR DYNAMIC RANGE WITH BOXCAR DIA
Innovative acquisition methods like BoxCar, available on new Thermo Scientific instruments can increase the MS1 dynamic range by more than one order of magnitude (Meier et al., 2018). This is particularly valuable for samples that are challenging like plasma, urine, and cerebrospinal fluid (CSF). Spectronaut gives access to the benefits of BoxCar in combination with DIA in its most recent release.
We have many more new features! Some of them are:
Deep learning assisted iRT calibration for library generation: Generate an empirical library with high precision iRT calibration even if your organism is an uncommon one.
- Highly improved memory management: Improved scalability for very large experiments (10,000s of runs). Spectronaut is even faster now!
- Implementation of quantification imputing strategies: Improved quantification strategies for missing values.
«Spectronaut’s novel PTM localization algorithm puts a powerful tool in our hands, providing exciting new possibilities in phosphoproteomics research.»
Prof. Dr. Jesper Velgaard Olsen,
CPR University of Copenhagen