Plasma glycoproteome analysis in clinical biomarker research

Together with the group of scientist from the ETH Zurich and ISB Seattle, Biognosys contributed to a pioneering paper on high-throughput plasma glycoproteome analysis. 

The paper describing biomarker validation workflow in plasma sub-proteome is just published in Molecular & Cell Proteomics.

We demonstrated that 48 N-glycoproteins spanning five orders of magnitude in abundance can be reproducibly quantified with multiplexed scheduled MRM approach.  Furthermore, a set of clinically-relevant markers was quantified across 120 samples from patients with three different malignancies enabling statistical testing with high sensitivity.


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