New targeted approaches for the quantification of human brain DIA datasets

Today we are highlighting an interesting paper published in Proteomics journal titled “New targeted approaches for the quantification of data-independent acquisition mass spectrometry”. 

The study, a collaborative effort from leading scientists and institutes in the mass spectrometry proteomics, experimental medicine and neuropathology fields, describes two new targeted approaches, using either classical data-dependent (DDA) repositories (not specifically built for DIA) or ad hoc mouse spectral libraries, which enable the profiling of human brain DIA dataset. The comparison of the results to both the most extended publically-available human spectral library and to a state-of-the-art untargeted method supports the use of these new strategies for comprehensive profiling of human samples by DIA acquisition.

The publication is available on the Proteomics journal homepage here.

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