From Evaluation to Implementation: Is the P2 Enrichment System the Right Fit for Your Lab?

The Challenge 

 

Carina Sihlbom Wallem’s team at the Proteomics Core Facility, University of Gothenburg (Sweden)—a part of BioMS and SciLifeLab—was seeking a robust and user-friendly solution for comprehensive plasma profiling. Their objective was to implement a platform capable of efficiently and cost-effectively processing large-scale sample sets, while maintaining high standards of data quality and reproducibility. 

The Solution 

 

Biognosys’ P2 Enrichment System is transforming plasma proteomics by enabling deep profiling of low-abundance proteins in human plasma and other biofluids. Powered by proprietary enrichment particles and optimized reagents, the system delivers exceptional plasma depth, reproducibility, and high-throughput performance—making it ideally suited for large-cohort studies. 

 

The team at the University of Gothenburg engaged in detailed discussions with Biognosys to explore the potential of implementing the P2 Enrichment System in their core facility. Following a comprehensive evaluation, they chose to proceed with the adoption of the platform. Below, Carina Sihlbom Wallem, Head of Unit at the Proteomics Core Facility, shares her firsthand experience with the implementation process.

 

 

 

User Perspective: Carina Sihlbom Wallem Reflects on Adopting the P2 Platform

 

Can you tell us about your organization and the mission that drives your work? 

We are an open-access academic facility specializing in advanced mass spectrometry-based proteomics, including the analysis of post-translational modifications and protein quantification. It is incredibly rewarding to contribute to cutting-edge research projects, and I am particularly passionate about leveraging the latest technological advancements. This field thrives on continuous innovation. 

 

What key benefits does P2 bring to your customers, and how does it enhance your existing plasma proteomics offering? 

Our goal is always to detect as many proteins as possible. Many disease-related biomarkers remain elusive due to their low abundance, so increasing the number of quantifiable circulating proteins is crucial. The P2 platform enables comprehensive, unbiased protein discovery at a cost-effective rate for users. 

  

Can you walk us through how you implemented P2 in your lab and what the role of the Biognosys implementation team was in this process?

Before implementation, we held several productive virtual meetings to discuss the methodology, protocols, and required materials. Our samples were initially analyzed at Biognosys, followed by an on-site visit from the project manager. During this visit, the same samples were processed and analyzed in our facility under the guidance of the implementation team. The entire process was expertly coordinated, meeting our expectations and demonstrating the team’s high level of competence.