Plasma is the most frequently investigated biological fluid in biomedical research mainly due to the easy access and the wealth of information it offers. Quantitative levels of selected plasma proteins can provide a snapshot of the health status of an individual and offer insights into disease onset or therapy response. These factors make plasma the model system of choice when investigating novel medical treatments and diagnostics.
Routine plasma proteomics applications are challenged by the complexity of the workflow, the low multiplexing possibilities, and the limited number of target proteins that can be accurately quantified. To that extent researchers are faced with many unanswered questions when it comes to plasma proteomics research.
To address the limitations of the existing tools, Biognosys' scientists have developed a portfolio of solutions for high-throughput and high-multiplexed quantification of human plasma proteins that cover a complete workflow from sample preparation to data analysis.
Absolute quantification of hundreds of human plasma proteins through the combination of quantitative capabilities of MRM/PRM with the comprehensiveness of DIA.
A high-throughput all-in-one sample preparation kit that enables processing of 96 cell cultures or plasma samples in parallel for all mass spectrometry proteomic workflows.
Multiplexed Assay Panel for absolute quantification of 100 proteins in human plasma/serum samples. PlasmaDive™ Multiplexed Assay Panel includes sample preparation kit, SIS peptides, the corresponding assay panel, and SpectroDive™ software for data analysis.
Professional software for setting up signal processing and analysis of MRM and PRM measurements. Advanced peak picking algorithms enable extremely fast analysis of large datasets.
Proteomics software for the analysis of data independent acquisition (DIA) measurements. Enables maximal proteome coverage and data completeness by utilizing the power of Hybrid Libraries – combining core proteome libraries (project or resource libraries) with sample specific libraries (directDIA)
Ease of Use
Complete workflow from sample preparation to data analysis
Protein target lists covering more than 500 plasma proteins for native and depleted plasma
Unmatched Multiplexing Capacity
Allowing the quantification of hundreds of proteins per plasma sample in one single run
Enabling the analysis of thousands of samples by seamless adaptation to automated liquid handling systems
Based on cutting-edge discovery and targeted proteomics mass spectrometry technology developed in-house
Biognosys scientists support you with establishing a complete work ow in your laboratory
Mayr M. Plasma Proteomics in Epidemiology: are we measuring the correct apolipoproteins for cardiovascular disease risk assessment? Webinar, May 2017.
Pechlaner R, et al. Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. J Am Coll Cardiol. 2017;69(7):789-800.
Cantonwine DE, et al. Evaluation of proteomic biomarkers associated with circulating microparticles as an effective means to stratify the risk of spontaneous preterm birth. Am J Obstet Gynecol. 2016 May;214(5):631.e1-631.e11.
Yin X, et al. Plasma Proteomics for Epidemiology: Increasing Throughput With Standard-Flow Rates. Circ Cardiovasc Genet. 2017; 10(6).
If you’re interested in learning more about our plasma proteomics tools, don’t hesitate to contact us. We would be pleased to schedule a meeting and support you with all of your proteomics needs.
Let us help you do great proteomics!
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