Today Biognosys released an application note “Comparison of Static and Dynamic Segments in Data-Independent-Acquisition Experiments”.
Data independent acquisition (DIA) methods are based on the parallel acquisition of broad ranges of peptide precursors. The distribution of the precursor masses, however, is not equally distributed over the mass range. An obvious solution is to use broad windows where the precursor density is low and narrow windows where the density is high, instead of using static windows across the whole mass range.
In this application note we look into the benefits of using an optimized dynamic window method compared to using one simple standard method with static windows for all samples and give recommendations for the selection of optimal mass ranges on Orbitrap instruments.
The application note is published on our Science Hub, a library that contains scientific and technical information related to Biognosys technology, products and services. It can also be downloaded directly using the following link: