Post-translational modifications (PTMs) are the covalent modifications of proteins that occur during or after biosynthesis. Most commonly known PTMs are phosphorylation, glycosylation, ubiquitination, methylation, acetylation and lipidation. PTMs play a key role in many cellular processes, regulation of protein activity, localization and interaction of modified proteins with other proteins and cellular molecules such as nucleic acids, lipids, and cofactors. Biognosys’ discovery proteomics technologyis ideally suited to provide highly-multiplexed identification and quantification of protein PTMs for a wide variety of applications.
You are likely to benefit if you are looking to:
- Identify PTMs that are modulated during disease progression or other processes
- Discover critical PTMs that are responsive to compound treatment
- Identify PTMs that are surrogate biomarkers for effective drug treatment, toxicity or drug resistance